Phytochemical profile, antioxidant and cytotoxic activities of the carob tree (Ceratonia siliqua L.) germ flour extracts. | - CCMAR -

Journal Article

TitlePhytochemical profile, antioxidant and cytotoxic activities of the carob tree (Ceratonia siliqua L.) germ flour extracts.
Publication TypeJournal Article
AuthorsCustódio, L, Escapa, ALuísa, Fernandes, E, Fajardo, A, Aligué, R, Alberício, F, Neng, N, Nogueira, JManuel Flo, Romano, A
Year of Publication2011
JournalPlant Foods Hum Nutr
Volume66
Issue1
Date Published2011 Mar
Pagination78-84
ISSN1573-9104
KeywordsAntioxidants, Fabaceae, Galactans, HeLa Cells, Humans, Mannans, Phenols, Plant Extracts, Plant Gums, Theophylline
Abstract

This work aimed to evaluate the phytochemical content and to determine the antioxidant and cytotoxic activities of methanol extracts of the carob tree (Ceratonia siliqua L.) germ flour. The extracts were rich in phenolic compounds, had considerable antioxidant activity, and reduced the viability of cervical (HeLa) cancer cells. The chemical content and the biological activities of the extracts were significantly affected by gender and cultivar. Female cultivar Galhosa had the highest levels of phenolic compounds, and the highest antioxidant activity. Extracts from the hermaphrodite trees and from the female cultivars Galhosa and Costela/Canela exhibited the highest cytotoxic activity. The most abundant compound was theophylline. The phenolic content was correlated to both antioxidant and cytotoxic activities. Our findings provide new knowledge about the health implications of consuming food supplemented with carob germ flour.

DOI10.1007/s11130-011-0214-8
Sapientia

http://www.ncbi.nlm.nih.gov/pubmed/21399924?dopt=Abstract

Alternate JournalPlant Foods Hum Nutr
PubMed ID21399924
CCMAR Authors