Matrix Gla protein repression by miR-155 promotes oncogenic signals in breast cancer MCF-7 cells | - CCMAR -

Journal Article

TitleMatrix Gla protein repression by miR-155 promotes oncogenic signals in breast cancer MCF-7 cells
Publication TypeJournal Article
AuthorsTiago, DM, Conceição, N, Caiado, H, Laizé, V, M. Cancela, L
Year of Publication2016
JournalFEBS Letters
Volume590
Issue8
Date Published2016 Apr
Pagination1234-1241
ISSN1873-3468
Abstract

MGP is a protein that was initially associated with the inhibition of calcification in skeleton, soft tissues, and arteries, but more recently also implicated in cancer. In breast cancer, higher levels of MGP mRNA were associated with poor prognosis, but since this deregulation was never demonstrated at the protein level, we postulated the involvement of a post-transcriptional regulatory mechanism. In this work we show that MGP is significantly repressed by miR-155 in breast cancer MCF-7 cells, and concomitantly there is a stimulation of cell proliferation and cell invasiveness. This study brings new insights into the putative involvement of MGP and oncomiR-155 in breast cancer, and may contribute to develop new therapeutic strategies.

DOI10.1002/1873-3468.12155
Sapientia

http://www.ncbi.nlm.nih.gov/pubmed/27009385?dopt=Abstract

Alternate JournalFEBS Lett.
PubMed ID27009385